"Afpak" is Afghanistan-Pakistan. With Al-Qaeda and the Taliban moving freely between the tribal areas of the two countries it no-longer makes to separate them. Pakistan is currently in a state of civil war; the opposing sides are the pro-West government and the Islamo-fundamentalist "tribes". In a substantial part of the country, the North-West frontier abutting Afghanistan, the rule of law does not apply.
Let's not forget that Pakistan has 100 nukes and the means to deliver them. Back in 1994 in South Africa as the ANC was about to take over from the Apartheid regime the decision was taken to dismantle the few nuclear warheads they had and transport the sensitive components to the USA for "safe-keeping". America has never given them back, and never will.
If the current government of Pakistan looks like losing the civil war it would be a good idea to ship their nukes out before Al-Qaeda takes over.